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Get Your Liver Ready for Post-Holiday Work Resumption! Are You Prepared to "Revitalize"?

2025-02-8

The joyous Spring Festival gatherings have come to an end. The lingering flavors of hot pot and barbecue still remain on the tip of the tongue. However, the "indulgent mode" of staying up late to watch dramas and toasting has silently taken a toll on our livers. After resuming work, do you often feel tired and lacking in energy, have a poor appetite, and even notice a dull complexion and frequent breakouts in the mirror? Beware, these could be "distress signals" sent by the liver! (Of course, some of these symptoms might just be due to reluctance to go back to work, just kidding!)

As the body's "detoxification factory", the liver works around the clock to metabolize toxins and break down fat for us. The sumptuous feasts and disrupted schedules during the Spring Festival have undoubtedly overloaded it. According to data from the National Health Commission/ "China Health Statistics Yearbook", during the Spring Festival, the detection rate of abnormal liver function has increased by an average of 25% - 35% compared to before the festival (alcoholic liver injury and fatty liver account for the highest proportion). And the abnormal rate among the young group (20 - 40 years old) exceeds 45% (usually caused by metabolic disorders due to a combination of staying up late, drinking, and high - fat diets).

Consumers are increasingly aware in their daily lives that liver protection is urgent. Tmall Health released the "Insight into Consumption Scenarios and Populations in the Health Care and Nourishment Industry", showing that demand scenarios closely related to work have increased, such as vitality replenishment and workplace recovery.

Data Source: Tmall Health "Insight into Consumption Scenarios and Populations in the Health Care and Nourishment Industry"
Note: The statistical caliber of UV growth rate is from June 2023 - June 2024 vs June 2022 - June 2023

Consumers hope to replenish their vitality in the fast - paced life to meet the daily challenges. People aged 25 - 30 are more concerned about special medical foods, those aged 30 - 34 pay more attention to health foods that supplement vitamins and minerals, and prefer to buy portable products to meet immediate needs in life. Men over 40 years old prefer health - preserving teas. In terms of the "workplace recovery" demand, office workers hope to adjust the healthy operation of various organs in the body to achieve a better state for efficient work and social interaction. They pay more attention to eye care, intestinal health, liver care, and emotional well - being.

Data Source: Tmall Health "Insight into Consumption Scenarios and Populations in the Health Care and Nourishment Industry"

In recent years, the market for liver - protecting and liver - nourishing products has shown strong and stable consumer demand. The popularity of topics related to liver nourishment and protection on domestic online social platforms has increased by 40.5% year - on - year. The core functional demands that consumers care about mainly include: promoting metabolism and detoxification, dietary regulation, improving physical and mental states, and sobering up from alcohol. The challenges faced by the industry lie in how to more accurately meet the increasingly refined and specific needs of consumers, and how to expand more usage scenarios and innovate product categories while ensuring product effectiveness.

Data Source: CBNData, "2023 Whole - Channel Population Research Data on Health Products"

PQQ Regulates Energy Metabolism

Animal and cell culture studies have shown that PQQ is beneficial for reducing the accumulation of visceral and liver fat. In addition to inhibiting lipogenesis, PQQ can also increase the number and function of mitochondria, thereby improving lipid metabolism. In addition to diet - induced obesity, PQQ also improves programmed obesity in offspring through maternal supplements and alters the gut microbiota, thus reducing the risk of obesity. In the progression of obesity, PQQ alleviates mitochondrial dysfunction and obesity - related inflammation, thereby improving the progression of obesity - related comorbidities, including non - alcoholic fatty liver disease, chronic kidney disease, and type 2 diabetes. Overall, PQQ has great potential as an anti - obesity agent and for preventing obesity - related complications [1].

Image Source: Reference 1

PQQ Improves Liver Injury

The liver - protecting mechanisms of PQQ include but are not limited to:
① Significantly improving acute alcoholic liver injury by reducing liver marker enzymes, including serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and increasing the levels of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH - Px), and catalase (CAT) in the liver. ② It can also significantly reduce the content of liver triglyceride (TG) and malondialdehyde (MDA).
③ Alleviating alcohol - induced oxidative damage by activating the NF - E2 - related factor 2 (Nrf2) - mediated signaling pathway and inhibiting the Toll - like receptor 4 (TLR4) - mediated nuclear factor - κB (NF - κB) signaling pathway [2].

Image Source: Reference 2

In liver - protecting products, pyrroloquinoline quinone (PQQ) is often used in combination with other liver - protecting ingredients due to its antioxidant and mitochondrial - protective effects.
 Silymarin stabilizes the liver cell membrane, and PQQ reduces oxidative damage by protecting mitochondria. The combination of the two can comprehensively support liver repair and function maintenance.
 As a precursor of GSH, NAC replenishes the antioxidant reserve, and PQQ reduces mitochondrial oxidative stress, jointly reducing the burden on the liver.
 Curcumin alleviates the inflammatory response, and PQQ protects mitochondrial function. The combination improves fatty liver and hepatitis - related damage. It can also be paired with black pepper extract to improve the absorption rate of curcumin.
 Milk thistle supports liver cell repair, and PQQ enhances mitochondrial energy metabolism, promoting liver regeneration.
 B - group vitamins support enzyme activity, and PQQ optimizes mitochondrial efficiency, jointly enhancing liver metabolic capacity.
 Zinc and selenium strengthen the endogenous antioxidant system, complementing the exogenous antioxidant effect of PQQ.
 Choline promotes fat transport, and PQQ enhances mitochondrial fatty acid oxidation, jointly improving non - alcoholic fatty liver disease (NAFLD).
 Alpha - lipoic acid (ALA) and PQQ jointly scavenge free radicals to protect liver cells from oxidative damage.

Image Source: Brand's Taobao product details page

[1] Mohamad Ishak NS, Ikemoto K. Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression. Front Mol Biosci. 2023 May 5;10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340; PMCID: PMC10196175.
[2] Qian L, Yang F, Lin X, Jiang S, Zhang Y, Tang Y. Pyrroloquinoline quinone ameliorates liver injury in mice induced by cyclophosphamide. Environ Sci Pollut Res Int. 2022 Apr;29(20):30383-30393. doi: 10.1007/s11356-021-17990-6. Epub 2022 Jan 8. PMID: 34997497.

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